This dataset contains place-level (incorporated and census-designated places) social determinants of health (SDOH) measures from the American Community Survey 5-year data for the entire United States—50 states and the District of Columbia. Data were downloaded from data.census.gov using Census API and processed by the Centers for Disease Control and Prevention (CDC), Division of Population Health, Epidemiology and Surveillance Branch. The project was funded by the Robert Wood Johnson Foundation in conjunction with the CDC Foundation. These measures complement existing PLACES measures, including PLACES SDOH measures (e.g., health insurance, routine check-up). These data can be used together with PLACES data to identify which health and SDOH issues overlap in a community to help inform public health planning.